By J.J. Broerse, T.J. Macvittie
`...a ``must'' within the library of scientists, biologists and physicists who're excited by TBI utilized to healing malignant diseases.'
Blut, 51:4 (1985)
Read Online or Download Response of Different Species to Total Body Irradiation PDF
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Extra resources for Response of Different Species to Total Body Irradiation
Example text
000 Gy) the toxicity of TBI is due to disturbances in two self renewal systems, the hemopoietic system and the gastrointestinal mucosa. e. stem cells, differentiating cells and functional end cells. The stem cells are the most radiosensitive and dose limiting cells. The end cells are hardly influenced by the radiation. Radiation induced deficits in the stem cell compartment will cause symptoms by not replacing end cells. Lack of platelets and white cells mucosa will cause losses in body fluids and electrolytes.
R. L. Jessup. Effect of age on radiation mortality in the Chinese hamster. Radiol. , 20 (1963) p. 288. 22. E. G. Moran. Problems in the chemotherapy of cancer in the neonate. Am. J. Rad. Hem. , 3 (1981) p. 287. 23. A. Bleyer. Delayed toxicities of chemotherapy on childhood tissues. Front. Radiat. Ther. , 16 (1982) p. 50. 24. A. W. Griffin. White matter necrosis, mineralizing microangiopathy and intellectual abilities in survival of childhood leukemia; Association with central nervous system irradiation and methotrexate therapy.
Hypothesis 3 requires that these numbers are approximately equal. For mice, rats and monkeys, this is indeed the case. In dogs a four fold difference is found. 0 Pegg 1966, with exception of the dog (13). 60 Gy. 0 Gy TBI. The precision of the comparison is influenced by several factors. The homing fraction of intravenously infused bone marrow cells is known only for mice. The LDso for dogs and rhesus monkeys are less accurate because of greater dosimetric problems and less animals per points. If the LDSO for dogs' is 10% higher than the one observed and this is within the margins of dosimetric error in the large, inhomogenous volume of the dog the differences between the last two columns in table 2 would be only a factor 2 for dogs.