Molecular Imprinting: Principles and Applications of Micro- by Lei Ye

By Lei Ye

Molecular imprinting is without doubt one of the best easy methods to fabricate practical polymer buildings with pre-defined molecular popularity selectivity. Molecularly imprinted polymers (MIPs) were used as antibody and enzyme mimics in a lot of purposes. the exceptional balance and simple coaching make MIPs excellent substitutes for biologically derived molecular reputation materials, Read more...

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Extra info for Molecular Imprinting: Principles and Applications of Micro- and Nanostructure Polymers

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Whitcombe et al. described one novel functional monomer for the preparation of MIPs against ampicillin, an antibiotic (Fig. 8), relying on this principle [30]. To target the carboxylic acid (in its anionic form), they prepared a polymerisable version (21) of the previously reported receptor. Unfortunately, the binding of this monomer to carboxylates (ca. 280 M−1 in DMSO-d6) was an order of magnitude lower than the receptor upon which the monomer was based. It was suggested that the decrease in binding strength arose from the electron-releasing group through which the polymerisable function was introduced.

Nature, 418, pp. 399–403. 17. , and Zimmerman, S. C. Cross-linked dendrimer hosts containing reporter groups for amine guests. J. Am. Chem. , 125, pp. 3424–3425. 18. Beil, J. , and Zimmerman, S. C. (2004). A monomolecularly imprinted dendrimer (MID) capable of selective binding with a tris(2-aminoethyl) amine guest through multiple functional group interactions. Chem. , pp. 488–489. 19. , and Zimmerman, S. C. (2009). Switching the selectivity of a polyglycerol dendrimer monomolecularly imprinted with D-(-)fructose.

619–630. 13. Umpleby, R. , Rushton, G. , Shah, R. , Rampey, A. , Bradshaw, J. , Berch, J. , and Shimizu, K. D. (2001). Recognition directed siteselective chemical modification of molecularly imprinted polymers. Macromolecules, 34, pp. 8446–8452. 14. , Whitcombe, M. , and Vulfson, E. N. (2000). Enhancement of selectivity of imprinted polymers via postimprinting modification of recognition sites. Polymer, 41, pp. 5583– 5590. 15. , Fouace, S. and Steinke, J. H. G. (2004). Novel stereoselective molecularly imprinted polymers via ring-opening metathesis polymerization.

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