Mitochondrial Function in Lung Health and Disease by Viswanathan Natarajan, Narasimham L. Parinandi

By Viswanathan Natarajan, Narasimham L. Parinandi

Mitochondria, also known as the “powerhouses” of the cellphone, generate adenosine triphosphate (ATP) by means of oxidative phosphorylation or OXPHOS, and keep mobile homeostasis. as well as producing ATP, mitochondria are occupied with law of mobile cycle, proliferation, loose radical construction, innate immune responses and apoptosis. Mitochondrial functionality in Lung well-being and Disease fills the present hole within the literature and descriptions the becoming scientific relevance of mitochondrial disorder. at the moment, there isn't any evaluation at the position of mitochondria in pulmonary illnesses and this quantity specializes in the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung damage, irritation, fix and transforming. in addition, as well as their well-recognized position in mobile strength creation and apoptosis, mitochondria seem to play a job in lots of breathing illnesses and lung melanoma. Chapters are written via top quality researchers and clinicians and description the facts for mitochondrial biogenesis in inhalational lung harm, COPD and asthma.

Show description

Read Online or Download Mitochondrial Function in Lung Health and Disease PDF

Best pulmonary & thoracic medicine books

Endothelium : molecular aspects of metabolic disorders

The functionality and existence span of endothelial cells have a wide effect upon the standard and expectancy of an individual's existence. in the course of low perfusion, the variation of alternative cells to hypoxia precipitate the competitive development of ailments. even supposing the scientific reports have convincingly proven that endothelial disorder happens each time the organic features or bioavailability of nitric oxide are impaired, in some of these eventualities, the position of endothelial cell-destructive procedure cross-talk is but poorly understood.

Endothelial Cytoskeleton

This e-book offers a concise synthesis of the present wisdom and up to date advances within the constitution, association and useful function of the cytoskeleton in endothelial cells. specific realization has been given to the various positive factors of the law of vascular functionality mediated by means of the endothelium.

Pleural Diseases

Now in an absolutely revised and up to date 6th version, Dr. Light's vintage textual content, Pleural ailments, provides much more targeted content material at the pathophysiology, medical manifestations, prognosis, and administration of pleural ailments. The text’s easy, single-author standpoint combines procedural services, insights on fresh technical advances, and transparent ideas for either analysis and therapy.

Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide

This publication is a state-of-the artwork assessment for clinicians and dieticians with an curiosity in food and inflammatory bowel illnesses (Crohn’s illness, ulcerative colitis). the quantity covers new facts approximately nutritional chance elements for Crohn’s illness and ulcerative colitis, examines the organization among vitamin and microbiome, describes a number of the diets within the administration of those ailments, and discusses macro- and micronutrient deficiency that happens in such sufferers.

Additional info for Mitochondrial Function in Lung Health and Disease

Example text

Am J Physiol Lung Cell Mol Physiol. 2003;284:L26–38. Asikainen TM, White CW. Antioxidant defenses in the preterm lung: role for hypoxiainducible factors in BPD? Toxicol Appl Pharmacol. 2005;203:177–88. Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, et al. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 2006;291:L1101–11. Warner BB, Stuart LA, Papes RA, Wispe JR. Functional and pathological effects of prolonged hyperoxia in neonatal mice.

Ascorbic acid; chemistry, biology and the treatment of cancer. Biochim Biophys Acta. 2012;1826:443–57. 73. Skulachev VP. A biochemical approach to the problem of aging: “megaproject” on membranepenetrating ions. The first results and prospects. Biochemistry (Mosc). 2007;72:1385–96. 1 Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases 21 74. Bakeeva LE, Barskov IV, Isaev NK, Kapelko VI, Kazachenko AV, et al. Mitochondriatargeted plastoquinone derivatives as tools to interrupt execution of the aging program.

104. Fahn HJ, Wang LS, Kao SH, Chang SC, Huang MH, Wei YH. Smoking –associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues. Am J Respir Cell Mol Biol. 1998;19:901–19. 105. Reddy PH. Mitochondrial dysfunction and oxidative stress in asthma: implications for mitochondria-targeted antioxidant therapeutics. Pharmaceuticals (Basel). 2011;25:429–56. 106. Comhair SA, Ricci KS, Arroliga M, Lara AR, Dweik RA, Song W, Hazen SL, Bleecker ER, Busse WW, Chung KF, et al. Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma.

Download PDF sample

Rated 4.33 of 5 – based on 22 votes