Interventional Radiological Treatment of Liver Tumors by Andy Adam, Peter R. Mueller

By Andy Adam, Peter R. Mueller

Interventional radiological thoughts have gotten more and more vital within the remedy of either fundamental and secondary malignant liver tumours. surgical procedure for liver tumours should be potent yet incorporates huge hazards and new concepts have lately been constructed. This quantity presents an account of interventional radiological tools via many of the maximum specialists within the box. It comprises chapters on cryotherapy, chemoembolization and radiofrequency ablation and an intensive bankruptcy on imaging concepts. The medical heritage of those innovations, the pathology of the illnesses concerned and an research of extra conventional surgical equipment also are defined. this article brings jointly the most recent advances during this fast-developing box.

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Libbrecht L, Desmet V, Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int 2005; 25: 16–27. 23. International Working Party. Terminology of nodular lesions of the liver: recommendations of the World Congress of Gastroenterology Working Group. Hepatology 1995; 22: 983–93. 24. Terada T, Nakanuma Y. Survey of iron-accumulative macroregenerative nodules in cirrhotic livers. Hepatology 1989; 5: 851–4. 25. Aihara T, Noguchi S, Sasaki Y, et al. Clonal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis.

A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2007; 25: 4637. 63. Schwartz J, Schwartz M, Lehrer D, et al. Bevacizumab in hepatocellular carcinoma (HCC) in patients without metastases and without portal vein invasion. J Clin Oncol 2005; 23: 4122. 64. Abbruzzese JL, Thomas MB. Opportunities for targeted therapies in hepatocellular carcinoma. J Clin Oncol 2005; 23: 8093–108. 65. Philip PA, Mahoney MR, Allmer C, et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer.

Recent advances have resulted in modest increments in survival, primarily due to the introduction of new cytotoxic and biological agents but partly due to the development of more sophisticated radiological techniques that allow the diagnosis of liver metastases earlier, often while the patient is asymptomatic, making for an apparent increase in survival. Capecitabine is a fluoropyrimidine precursor that is converted to 5-FU by a series of enzymatic reactions. Unlike 5-FU, its oral bioavailability is predictable.

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