Cilia and Mucus: From Development to Respiratory Defense by Matthias Salathe

By Matthias Salathe

This publication information advances in examine concerning cilia, mucus, and mucociliary clearance, reading adjustments in mucus expression and goblet telephone metaplasia, and assessing the facility of the mucociliary method to reply to abnormalities. acknowledges that cilia and dynein hands play pivotal roles in constructing mammalian embryos!Examines the function of genetics in general and irregular ciliary function!Discussing clinical basics, present diagnostic innovations, and clinically verified remedies, Cilia and Mucus analyzes the legislation of ciliary waves on the mobile point considers irregularities of higher and decrease airlines and cilia in structures of the physique explores capability modulators of airway mucin secretion proposes a singular treatment for airway hypersecretion as a result of the epidermal progress issue cascade clarifies gamma digital camera imaging to degree mucociliary clearance describes the impact of purinergic receptors and dry powder mannitol on airway passages and extra! With contributions from over a hundred overseas researchers and clinicians, and containing over 1300 references, drawings, pictures, tables, and equations, Cilia and Mucus is a special single-source reference for pulmonologists, physiologists, immunologists, allergists, otolaryngologists, pediatricians, microbiologists, simple scientists, and graduate and clinical college scholars in those disciplines.

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Infinite models for ciliary propulsion. J Fluid Mech 49:209–222, 1971. RE Johnson, CJ Brokaw. Flagellar hydrodynamics: A comparison between resistiveforce theory and slender body theory. Biophys J 25:113–127, 1979. J Lighthill. Reinterpreting the basic theorem of flagellar hydrodynamics. Journal of Engineering Mathematics 30:25–34, 1996. MA Sleigh, MEJ Holwill. Energetics of ciliary movement in Sabellaria and Mytilus. J Exp Biol 50:733–743, 1969. J Lighthill. Flagellar Hydrodynamics. SIAM Review 18:161–230, 1976.

53. IR Gibbons, BH Gibbons, G Mocz, DJ Asai. Multiple nucleotide-binding sites in the sequence of the dynein β heavy chain. Nature 352:640–643, 1991. 54. K Ogawa. Four ATP-binding sites in the midregion of the β heavy chain of dynein. Nature 352:643–645, 1991. 55. DJ Asai, SM Beckwith, KA Kandl, HH Keating, H Tjandra, JD Forney. The dynein genes of Paramecium tetraurelia: Sequences adjacent to the catalytic P-loop identify cytoplasmic and axonemal heavy chain isoforms. J Cell Sci 107:839–847, 1994.

Mol Biol Cell 11:523–529, 2000. 22. G Piperno. Functional diversity of dyneins. Cell Motil Cytoskel 17:147–149, 1990. 23. G Piperno, Z Ramanis, EF Smith, WS Sale. Three distinct inner dynein arms in Chlamydomonas flagella: Molecular composition and location in the axoneme. J Cell Biol 110:379–389, 1990. 24. O Kagami, R Kamiya. Translocation and rotation of microtubules caused by multiple species of Chlamydomonas inner-arm dynein. J Cell Sci 103:653–664, 1992. Cytoplasmic Dynein-2 and Ciliogenesis 15 25.

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