On the structure of pure riemann matrices with by Albert A.A.

By Albert A.A.

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1995). Molecular characterization of the male-specific lethal-3 gene and investigation of the regulation of dosage compensation in Drosophila. Development 121, 463–475. , Kuroda, M. , and Baker, B. S. (1993). Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell 72, 39–49. , and Lucchesi, J. C. (1998). Targeting of MOF, a putative histone acetyl transferase, to the X chromosome of Drosophila melanogaster. Dev. Genet. 22, 56–64.

However, in both systems some genes do escape compensation. Mammalian genes that retain active homologs on the Y have no need to undergo compensation (Jegalian and Page, 1998). , 1966). In addition, genes with sex-limited expression, and those with autosomal homologs that can blunt the impact of their loss from the Y chromosome, may escape compensation (reviewed in Baker and Belote, 1983; Lucchesi and Manning, 1987). These observations reinforce the notion that compensation occurs on a gene-by-gene basis, as needed to respond to the loss of genetic information.

Nature 386, 275–279. Lucchesi, J. , and Manning, J. E. (1987). Gene dosage compensation in Drosophila melanogaster. Adv. Genet. 24, 371–429. Lucchesi, J. , and Tax, F. E. (1982). A new male-specific lethal mutation in Drosophila melanogaster. Genetics 100, s42. Lyman, L. , Kelley, R. , and Kuroda, M. I. (1997). Drosophila malespecific lethal-2 protein: Structure/function analysis and dependence on MSL-1 for chromosome association. Genetics 147, 1743–1753. Lyon, M. F. (1961). ). Nature 190, 372–373.

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