By D.R. Buhler and D.J. Reed (Eds.)
This actual quantity, Nitrogen and Phosphorus Solvents, is the second one in a entire and up to date sequence. The creation of latest nitrogen- and phosphorus- containing solvents utilized in has been observed via an explosion of information approximately their homes, toxicity and metabolism. Even a comparatively basic compound corresponding to N-methylformamide undergoes a fancy metabolic transformation in mammals. Such details, and different concerns contained during this quantity will provide researchers and scholars with a great details resource on smooth mechanistic toxicology, whereas aiding to supply a valid clinical foundation for exact overall healthiness danger assessment.
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Basic form) or its hydrochloride salt were used and were thought to result from direct stimulation of smooth muscle independent of nerve-mediated effects. HUMAN TOXICITY rc-Dibutylamine is a severe irritant to skin and mucous membranes of the nose, eyes, and respiratory tract. Exposure to this amine may result in some activation of the sympathetic branch of the autonomic nervous system as manifested by elevated blood pressure, eye pupil dilation and flushing of the skin. GENETIC TOXICITY Dibutylamine tested negative for mutagenicity using the Salmonella/microsome preincubation assay with 5 bacterial strains (TA97, TA98, TA100, TA1535, TA1537) in the presence and absence of rat or hamster S-9 fraction (Mortelmans et al 1986).
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Agric. Biol. Chem. 45, 2237-2244. Hanzlik PJ (1923) Toxicity and actions of the normal butylamines. / . Pharmacol. Exper. Therapeutics 20, 435-449. Hazardous Substances Data Bank (HSDB) (1989) National Library of Medicine, Bethesda, MD. Heyns K, Roeper H (1973) Gas Chromatographie trace analysis of volatile nitrosamines in various types of wheat flour after application of different nitrogen fertilizers to the wheat. ), IARC Scientific Publication No. 9. N-Nitroso Compounds in the Environment, pp.