Childhood Asthma by Stanley J Szefler, Soren Pedersen

By Stanley J Szefler, Soren Pedersen

This reference collects the most recent experiences at the improvement, prognosis, and remedy of early life bronchial asthma and provides present views on new applied sciences that may form the administration of pediatric bronchial asthma within the impending decade-illustrating how advances in pulmonary functionality dimension, inflammatory markers, imaging, and pharmacogenetics will improve the analysis and tracking of bronchial asthma in future years.

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435 References . . 436 18. Role of Allergen-Specific Immunotherapy in Childhood Asthma . . . . . . . . . . . . . . . . . . 447 Andrew H. Liu and Harold S. Nelson I. Introduction . . 447 II. Clinical Rationale for SIT in Childhood Asthma . . 448 III. Mechanisms of Action . . 454 IV. Key Parameters for Effective SIT . . 460 V. Alternative Routes of Administration for SIT . . 473 VI. Modified Allergen Extracts . . 475 VII. Conclusion . . 476 References . . 478 19.

To define the effects (if any) of maternal antibodies placenta on specific cellular immune responses in the neonate 2. There is gradual increase in the production of 2. To determine whether allergen-speicifc IgG antibodies allergen-specific IgE (and IgG) in allergic infants modulate IgE-mediated effector mechanisms 3. To determine why only a subgroup of infants with elevated allergen-specific IgE develop allergic symptoms Current knowledge: supported by sound experimental data and/or consistent observations Table 1 Perinatal Immune Development: Current Knowledge and Future Directions Regulation of Immune Functions and Risk for Allergy and Asthma 23 24 Figure 2 Prescott and Holt Differences between adult and neonatal responses.

These functions mature slowly in the postnatal period 2. To determine what factors modify APC maturation 3. To find strategies that can safely modify early immune development to prevent allergic immune responses T cell responses 1. Allergen-responsive T cell clones are evident in the neo- 1. To define the mechanism of perinatal T cell ‘‘ priming’’ and to determine the role of these natal period, although the significance of these is populations in subsequent immune development unclear 2. Neonatal T cells are more susceptible to postactivation 2.

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