Wheezing Disorders in the Pre-School Child: Pathogenesis and by Fernando D. Martinez, Simon Godfrey

By Fernando D. Martinez, Simon Godfrey

Wheezing issues in babies and children are one of the most typical and so much not easy difficulties dealing with the pediatrician. Wheezing issues in preschool kids occupy a wide a part of the pediatrician's time and represent a substantial burden at the supply of overall healthiness care. during this e-book, popular specialists familiarize clinicians with this frequently puzzling medical challenge. targeting sensible concerns, the authors divulge the inability of current information at the etiology and pathophysiology of the sickness technique, define the optimum method of prognosis and administration, and speak about early wheezing as a predictor of the improvement of continual respiration signs in later existence.

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Inhaled epinephrine Clinical trials using inhaled racemic epinephrine34,39,40 have suggested that some children may respond to this therapy with significant, albeit short-lasting, improvements in lung function tests and in clinical scores. The implication of these studies is that the mechanism of action of epinephrine is different from that of ␤2-agonists, and perhaps related not to bronchodilation but to a decrease in airway edema, especially in the upper airway. It is important to recall here that some infants with RSV have signs and symptoms of laryngeal obstruction,9 and it is possible that some involvement of the laryngeal mucosa may be present in many infants with acute RSV infection.

Chest physiotherapy is usually not required and may be counterproductive in very young children with severe airway obstruction. Although hydration is important, most infants with RSV-LRI can be fed orally and do not require more than maintenance fluids, if that. qxd 26 7/25/03 3:35 PM Page 26 WHEEZING DISORDERS IN THE PRESCHOOL CHILD should be paid to respiratory effort and oxygen saturation status. Children with confirmed RSV should preferentially be housed with no other uninfected young child, given the high likelihood of the latter becoming infected by direct contact or by transmission through hospital personnel.

44. Anonymous. Reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections. American Academy of Pediatrics Committee on Infectious Diseases. Pediatrics 1996; 97: 137–40. 45. Kim HW, Canchola JG, Brandt CD et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 1969; 89: 422–34. 46. Staat MA. Respiratory syncytial virus infections in children. Semin Resp Inf 2002; 17: 15–20. 47. Anonymous.

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