Textbook of influenza by Robert G. Webster, Arnold S. Monto, Thomas J. Braciale,

By Robert G. Webster, Arnold S. Monto, Thomas J. Braciale, Robert A. Lamb

The Textbook of Influenza is a entire source masking all elements of influenza, from the genetic and molecular biology of the virus via to medical features of the affliction and the newest drug advancements and coverings. This re-creation has been thoroughly revised and displays the combination of disciplines in regards to the emergence, evolution, pathogenesis and regulate of influenza viruses within the box of human and veterinary public health.

Textbook of Influenza examines the teachings learnt from the most recent pandemic and offers the present country of data for lots of but unresolved concerns with regards to virus starting place, unfold, pathogenesis and illness severity to higher organize for destiny pandemics. It covers the heritage to fresh advances in influenza genomics and opposite genetics that have allowed the identity of virus virulence elements and the research and reconstruction of influenza viruses comparable to the 1918 Spanish flu strain.

This re-creation is split into 8 key sections, containing chapters co-written through foreign specialists from either the medical and clinical groups, covering:
• Influenza Perspectives
• Structure and Replication
• Evolution and Ecology
• Epidemiology and Surveillance
• Immunology
• Vaccines and Vaccine Development
• Clinical features and Antivirals
• Public Health

Textbook of Influenza is for all these operating within the zone of influenza together with scientific and uncomplicated scientists, immunologists, molecular and structural virologists, public well-being officers and worldwide pandemic regulate planners.

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Example text

The agent, A/New Jersey 76, was finally determined to be an A (H1N1) virus of swine origin. It was known that pandemics were a result of type A animal viruses becoming adapted for human transmission. Past studies of antibodies present in the population had led to the hypothesis – the recycling theory – according to which A (H2N2) and then A (H3N2) viruses had circulated before, and that the next pandemic virus would be A (H1N1)-like [2]. On the basis of these facts, it was decided that this event likely represented the start of a new pandemic.

With the emergence of avian influenza A H5N1 in 2003, and with concerns about the availability of vaccine if a pandemic were to occur, many WHO Member States requested a dialogue to re-evaluate the way the WHO global surveillance system managed the sharing of influenza viruses and the benefits accruing from their use in vaccines and other products [58]. The heart of the issue was that some developing countries were concerned about potential difficulties securing H5N1 13 CHAPTER 1 vaccine developed from their own viruses.

This event was, in part, the inspiration in 1948 for the WHO Interim Commission to establish the World Influenza Centre in London and propose the organization of a laboratory network that would be coordinated by WHO to monitor influenza viruses infecting humans. By 1949, 38 countries had WHO-designated regional influenza laboratories and it was proposed that all countries eventually might have their own National Influenza Centers (NICs). In 1962, this nascent network of laboratories had grown to include two Collaborating Centers (CCs) for influenza (at the National Institute for Medical Research in London, United Kingdom and the Centers for Disease Control in Atlanta, United States) and 59 NICs.

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