By Martin Malmsten
The ebook covers the fundamentals of surfactant and polymer floor task and self-assembly, many of the forms of constructions shaped by way of such compounds, and the way they're utilized in drug supply. It additionally discusses solubilization of gear in micellar platforms, liquid crystalline stages shaped through PEO-PPO-PEO block copolymers and different copolymers and surfactants, prompted drug-release from liposome formulations, microemulsions shaped through ionic and nonionic surfactants, and masses extra.
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As a result of this, the bioavailability of the drug in tissues not related to the RES may Copyright 2002 by Marcel Dekker, Inc. All Rights Reserved. Micelles 45 be limited, and dose-limiting toxic side effects may occur in RES-related tissues. In this context, the use of colloidal drug carriers, such as micelles, liposomes, and emulsion droplets may offer a way to reduce the RES uptake. In particular, PEO-containing block copolymers are quite attractive in this context; due to this, the generally small size of micelles, and the slow disintegration time of PEOcontaining block copolymer micelles, such systems are quite interesting as drug carriers in intravenous drug delivery.