Proteoglycans in Lung Disease (Lung Biology in Health and by Hari G. Garg

By Hari G. Garg

Discusses new remedy ideas for malignant mesothelioma, pulmonary edema, fibrosis, bronchial asthma, emphysema, and bronchiectasis.Proteoglycans in Lung affliction considersglycosaminoglycans as novel healing brokers or goals in lung illness the position of proteoglycans in deciding upon mechanical habit of lung tissue hyaluronan and its receptors in wound therapeutic, irritation, vasculogenesis, and angiogenesis the influence of small proteoglycans on matrix meeting versican as a modulator of cellphone adhesion, migration, and proliferation antiproliferative task of heparin and its derivatives on pulmonary artery tender muscle cells the results of mechanical pressure on proteoglycans the services of proteoglycans within the vascular wall the impact of hypoxia on glycosaminoglycans within the lung made from greater than 1940 references, Proteoglycans in Lung disorder

Show description

Read or Download Proteoglycans in Lung Disease (Lung Biology in Health and Disease) PDF

Similar pulmonary & thoracic medicine books

Endothelium : molecular aspects of metabolic disorders

The functionality and lifestyles span of endothelial cells have a wide impression upon the standard and expectancy of an individual's lifestyles. in the course of low perfusion, the difference of other cells to hypoxia precipitate the competitive development of illnesses. even though the medical stories have convincingly proven that endothelial disorder happens at any time when the organic features or bioavailability of nitric oxide are impaired, in a majority of these eventualities, the position of endothelial cell-destructive method cross-talk is but poorly understood.

Endothelial Cytoskeleton

This ebook provides a concise synthesis of the present wisdom and up to date advances within the constitution, association and useful function of the cytoskeleton in endothelial cells. specific recognition has been given to the various positive aspects of the legislation of vascular functionality mediated by way of the endothelium.

Pleural Diseases

Now in an absolutely revised and up to date 6th variation, Dr. Light's vintage textual content, Pleural ailments, supplies much more centred content material at the pathophysiology, medical manifestations, prognosis, and administration of pleural illnesses. The text’s straight forward, single-author standpoint combines procedural services, insights on contemporary technical advances, and transparent ideas for either analysis and remedy.

Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide

This publication is a state-of-the artwork assessment for clinicians and dieticians with an curiosity in foodstuff and inflammatory bowel illnesses (Crohn’s affliction, ulcerative colitis). the quantity covers new facts approximately nutritional hazard elements for Crohn’s affliction and ulcerative colitis, examines the organization among nutrition and microbiome, describes a few of the diets within the administration of those illnesses, and discusses macro- and micronutrient deficiency that happens in such sufferers.

Additional info for Proteoglycans in Lung Disease (Lung Biology in Health and Disease)

Example text

FibroSvensson L, Aszo´di A, Reinholt FP, Fa¨ssler R, Heinega˚rd D, Oldberg A modulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem 1999; 274:9636–9647. Dolhnikoff M, Morin J, Roughley PJ, Ludwig MS. Expression of lumican in human lungs. Am J Respir Cell Mol Biol 1998; 19:582–587. Chakravarti S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C, Carroll H. Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican.

The characteristic transformation of cardiac endothelial cells into mesenchyme is impaired. These data demonstrate the critical importance of HA in development and confirm earlier suggestions that HA has a fundamental role in regulating cell migration. III. Hyaluronan in Diseased Lung HA content has been quantitated in bronchoalveolar lavage fluid (BALF) under a variety of pathologic lung conditions. In normal BALF, HA content is low, suggesting that potent endogenous mechanisms exist for regulating HA turnover.

Biochem J 1989; 261:801–809. 23. Valhmu WB, Palmer GD, Rivers PA, Ebara S, Cheng J-F, Fischer S, Ratcliffe A. Structure of the human aggrecan gene: exon-intron organization and association with the protein domains. Biochem J 1995; 309:535–542. 24. Doege KJ, Coulter SN, Meek LM, Maslen K, Wood JG. A human-specific polymorphism in the coding region of the aggrecan gene: variable number of tandem repeats produce a range of core protein sizes in the general population. J Biol Chem 1997; 272:13974–13979.

Download PDF sample

Rated 4.50 of 5 – based on 28 votes