By Gregg L. Semenza, Chandan K. Sen
The power of cells to experience and reply to alterations in oxygenation underlies a large number of developmental, physiological, and pathological approaches. This quantity presents a entire compendium of experimental ways to the learn of oxygen sensing in forty eight chapters which are written by means of leaders of their fields.
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Methods in enzymology xli Volume 352. Redox Cell Biology and Genetics (Part A) Edited by Chandan K. Sen and Lester Packer Volume 353. Redox Cell Biology and Genetics (Part B) Edited by Chandan K. Sen and Lester Packer Volume 354. Enzyme Kinetics and Mechanisms (Part F: Detection and Characterization of Enzyme Reaction Intermediates) Edited by Daniel L. Purich Volume 355. Cumulative Subject Index Volumes 321–354 Volume 356. Laser Capture Microscopy and Microdissection Edited by P. Michael Conn Volume 357.
27 [1] O2 sensing by model cell lines 11 between PC12 cells and type I carotid body cells is the molecular identity of the voltage-gated Ca2þ channels mediating stimulus-evoked secretion. 26,34 These two discrepancies highlight the limitations of PC12 cells as a model system for studying acute arterial chemoreception, but the two tissue types are likely to share common, O2-sensitive intracellular signaling pathways. Given their abundance and ease of maintenance, PC12 cells may yet prove more useful as a model system for studying cellular responses to chronic hypoxia at the molecular level.
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