By Karen Belkic
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Extra info for Molecular Imaging Through Magnetic Resonance for Clinical Oncology
Example text
These compounds must be present in high concentrations (≥ 1 – 2 mM) and must be small and mobile (with T2 relaxation times ≥ 10 – 20 ms). It should be noted that large macromolecules have T2 relaxation times in the µsec range [3-6]. 2 Characteristics of the metabolites evaluated by MRS Here, the basic characteristics of the metabolites evaluated by MRS are presented to provide the reader with an initial intuitive grasp of their meaning and importance. These will be discussed in more depth in Chapter 4 and thereafter.
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D. Clarke, Proton magnetic resonance spectroscopy in the brain: Report of AAPM MR Task Group #9, Med. Phys. 29, 2177-2197 (2002). [5] D. Spielman, In vivo proton MR spectroscopy: basic principles and clinical applications, Section for Magnetic Resonance Technologists Educational Seminars 3, 19-37 (2000). [6] K. Belkic, Magnetic resonance spectroscopy and spectroscopic imaging: a review of basic principles and achievements in oncology, J. Comp. Meth. Sci. Engin. 3, 505-533 (2003). W. A. J. R. Prince, MRI from picture to proton, Cambridge University Press, Cambridge, 2003.