Contemporary Topics in Immunobiology: T Cells by Osias Stutman (auth.), Osias Stutman (eds.)

By Osias Stutman (auth.), Osias Stutman (eds.)

And even i will keep in mind an afternoon whilst historians left blanks of their writings, I suggest for issues they did not comprehend. -Ezra Pound, Canto XIII * The prefaces to the former volumes of this sequence have all expressed in a variety of methods the particular motivation in the back of those collective efforts. there has been contract in so much circumstances that we face a few form of book explosion, and that the current kind of compact and custom-made stories might be of support, from either a conceptual and a in simple terms informational point of view. The goals of the sequence have been, and nonetheless are, to concentration recognition at the swiftly altering fields in the realm of immunology, and to give in each one bankruptcy the summation of effects generated by way of an investigator or team of Investigators, both as an research in their personal paintings or as a correlation of such paintings with the final box in query. the current quantity doesn't range in its development from its predecessors, even though it does pay attention to a unmarried aim, the T lymphocyte and its biology. the choice of matters in addition to individuals has been the only real responsi­ bility of this editor; in spite of the fact that, the particular structure and size of the person contributions was once left to the discretion and proposal of different authors. Even the types, starting from the concise assertion to the meticulously targeted evaluation, attest to the liberty of format.

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This last set of findings will be briefly discussed in this section. The term "traffic" has also been used to describe the rapid recirculation of small mature lymphocytes (mostly T) from blood into lymphoid tissues and back to blood, which takes place in hours (W. L. Ford and Gowans, 1969). , traffic of hemopoietic cells through the thymus). A. A Brief Description of Methods The use of CBA/H and CBA/HT6T6 mice (and their F 1 hybrids) allows the detection of three different cell types, characterized by their chromosome types: no markers (CBA/H), two small chromosomes (CBA/HT6T6), and one single small chromosome (the F 1 hybrid, CBA/HT6).

The sensitivity or resistance to steroids was also tested in the traffic model, and our unpublished results indicate that (I) the population of corticosteroid-resistant thymocytes within thymus grafts is in part derived from hemopOietic immigrants and (2) when thymus grafts from Modell animals pretreated with high doses of hydrocortisone (25 Ilg/kg body weight) were transferred to secondary thymectomized hosts, there was no evidence of export of the corticosteroid-resistant intrathymic population.

1975). , a cell that received some sort of thymic influence) present in liver and marrow, but absent from yolk sac. E). 1 and C; see EI-Arini and Osoba, 1973). It seems that additional study is necessary for clarification of these problems. Stutman 32 Table X. 5 1 1 1 CBA/H (host) 3 54 80 98 98 98 aThymus graft under the kidney capsule and subequent injection of 5x 106 liver cells from 15-16-day-old embryos. bFive to eight thymi were analyzed per point. The number of metaphases scored per graft ranged from 125 to 30l.

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