Chitosan for Biomaterials II by Rangasamy Jayakumar, M. Prabaharan, Riccardo A. A.

By Rangasamy Jayakumar, M. Prabaharan, Riccardo A. A. Muzzarelli

M. Prabaharan
R. Jayakumar
Polymeric Bionanocomposites as Promising fabrics for managed Drug

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H. Ragelle
A. des Rieux
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Chitosan and Chitosan Derivatives in Drug supply and Tissue Engineering

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Chitosan: A Promising Biomaterial for Tissue Engineering Scaffolds

X. Liu
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Chitosan-Based Biomaterials for Tissue fix and Regeneration

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Extra resources for Chitosan for Biomaterials II

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2 Amphiphilic Chitosan Derivatives . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Chitosan-Based Hydrogels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Biomedical Applications of Chitosan and Chitosan Derivatives . . . . . . . . . . . . . . 1 Gene Delivery by Chitosan and Chitosan Derivatives . . . . . . . . . . . . . . . .

The survival rate of mice that received 50 mg/kg paclitaxel in HGC nanoparticles increased substantially compared to 20 mg/kg PTX in Cremophor EL–ethanol solutions [120]. 2 Fatty Acid Derivatives of Chitosan Different fatty acids were used to generate amphiphilic chitosan derivatives: linoleic acid [66, 67], stearic acid [68, 70], and oleic acid [71] (Fig. 4). The stability of the micellar structure can be controlled by adjusting the balance between hydrophobic acyl groups and hydrophilic chitosan in an N-acyl chitosan.

The grafting of polymer chain onto chitosan is not limited to PCL. The grafting of PEG chains onto chitosan is widely described in the literature [87–91]. Recently, Casettari et al. grafted carboxylic acid-terminated PEG chains onto the primary amines of chitosan and compared the toxicity of the resulting grafted copolymer to chitosan [85]. However, the grafting of hydrophilic PEG chains was not enough to confer amphiphilic properties but can be coupled with the grafting of PCL chains. So, a heterografted chitosan bearing PCL and PEG chains was synthesized by Liu et al.

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