By Klaus-Peter Wilhelm, Peter Elsner, Enzo Berardesca, Howard I. Maibach
Spanning the numerous developments that experience taken position within the box because the First variation of this ebook used to be released, this moment version emphasizes the imaging of the surface in its entirety, instead of focusing exclusively on floor layers. the second one variation contains new chapters on applied sciences equivalent to in vivo confocal laser scanning microscopy, Raman spectroscopy, optical coherence tomography, nuclear magnetic imaging, high-resolution ultrasound, in vivo epidermis topometry, and multi-photon imaging of the outside.
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Extra resources for Bioengineering of the Skin: Skin Imaging & Analysis, 2nd Edition (Dermatology: Clinical & Basic Science)
Few belong to group 2. Thicker scales of groups from 3 to 5 are not found at all. This image analytical method is a valuable tool to assess xerosis vulgaris, or xerosis induced by soaps, irradiation, tape stripping, etc. The method has been successfully used on a variety of clinical studies, especially evaluating the efficacy of moisturizers. Disorders of keratinization with very thick scales are less suitable for this method of study. In black skin, scales adherent on the disc often appear dark because corneocytes contain undegraded melanosomes, limiting the usefulness of the method in this group.
30. Lavker RM, Zheng P, Dong G. Aged skin: a study by light, transmission, and scanning electron microscopy. J Invest Dermatol 1987; 88:S44. 31. Montagna W, Carlisle K. Structural changes in aging skin. Br J Dermatol 1990; 1225(suppl 35):61. 32. Kligman AM, Lavker RM, Grove GL, Stoudemayer TJ. Some aspects of dry skin and its treatment. In: Kligman AM, Leyden JJ, eds. Safety and Efficacy of Topical Drugs and Cosmetics. New York: Grune & Stratton, 1982:221. 33. Kligman AM. Regression method for assessing the efficacy of moisturizers.
OCT is very well suited for high-resolution imaging of the uppermost skin layers. In vivo MRI of skin is so far not yet established in dermatology, although studies have shown that HR-MRI of skin can be implemented with standard clinical tomographs and specially designed receive coils. However, MRI systems are usually not available and are too expensive for dermatological diagnostics, the acquisition time is on the order of several minutes, and the resolution is significantly worse than with HFUS and OCT.