By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual loss of life toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of recent medications, higher diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and instructing within the box of TB. It comprises a hundred colour photos and illustrations that convey readability to the knowledge offered. The atlas takes the weird strategy of masking a number of species histopathology, arguably the 1st and rather in all probability the single source to take action. It offers an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal versions. The editors have compiled info that is helping TB scientists to tell apart among the gains of all significant animal types to be had and to take advantage of them with their strengths and barriers in brain. The booklet presents tips for choosing the simplest animal model(s) to reply to particular questions and to check the efficacy of drug applicants.
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World Health Organization. 2010b. Neglected tropical diseases [online]. World Health Organization. int/neglected_diseases/diseases/en/ [Accessed January 9, 2010]. Chapter 2 Tuberculosis Biology and Drug Discovery Thomas Dick Contents Disease Manifestations and Treatment A Largely Unmet Medical Need The Challenge of TB Drug Discovery An Atlas for TB Drug Discovery References 14 15 16 17 17 M yc obact er ium t uber cu l o sis (MTB) is the causative agent of tuberculosis (TB). First discovered in 1882 by Robert Koch, the tubercle bacillus has an unusual waxy coat primarily made up of mycolic acids.
In the years since the establishment of the Novartis Institute for Tropical Diseases (NITD), an increasing amount of resources have been allocated toward searching for new antituberculosis agents that should overcome the increasing resistance to old antibiotics observed globally and that hopefully will also achieve clearance of MTB in significantly less time than is currently the case. The following chapters cover some aspects of our experiences in tuberculosis drug research from an animal model and histopathological perspective.
Goblet cells are no longer present. Ciliated cells extend to the bronchiolo-alveolar junction, gradually decreasing in number as they extend peripherally and maintaining the ciliary flow around the nonciliated Clara cells. There are direct communications between the lumen of membranous bronchioles and adjacent alveoli through Lambert’s canals. These are difficult to observe microscopically, but they have a definite role in collateral ventilation. Resolution of inflammatory changes may result in metaplastic growth of bronchiolar epithelium through Lambert’s canals.